Current Perspectives on the NF-κB Signaling Axis as a Potential Pharmacological Target in Cardiorenal Syndrome
Qian Liu, Xinting Wang, Peipei Cheng, Tianshu Yang, Chen Wang, Hua Zhou · 2025
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Description
Qian Liu and five co-authors review a master inflammation switch as a drug target when heart and kidney fail together. Their review was published in twenty twenty-five. This cardiorenal syndrome is complex, fast-moving, and deadly, with few good treatments.
The switch, NF-kappaB, enters the cell nucleus and turns on genes that drive inflammation and oxidative stress in both organs. The review gathers lab and clinical work on blocking it. It also singles out natural compounds that damp the switch in heart and kidney tissue at once, offering double protection. The authors discuss what such drugs would need to prove. Their synthesis maps a target that sits upstream of much of the damage.
Catalog record
| CREATOR | Qian Liu, Xinting Wang, Peipei Cheng, Tianshu Yang, Chen Wang, Hua Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |