Prognostic Significance and Mechanistic Insights of Rutin-Related Ferroptosis Gene Signature in Hepatocellular Carcinoma
Weifeng Yao, Hui Li, Yongle Zhang, Xufen Xia, Hai Wang, Zhen Zhang, Danfang Shi · 2025
Read Prognostic Significance and Mechanistic Insights of Rutin-Related Ferroptosis Gene Signature in Hepatocellular Carcinoma by Weifeng Yao, Hui Li, Yongle Zhang, Xufen Xia, Hai Wang, Zhen Zhang, Danfang Shi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12743547.txt.
Description
Liver cancer is hard to treat, and a plant compound called rutin has shown anti-tumor hints. Weifeng Yao and co-authors study whether rutin fights liver cancer through ferroptosis, a form of cell death driven by iron and fat damage. They combine cell experiments with large public cancer data sets.
In lab dishes, rutin slowed liver cancer cell growth, movement, and division in step with dose. Data mining tied five genes to both rutin and the death pathway. A risk score built from those genes split patients into groups with clearly different outlooks, and it held up in two outside data sets. One gene stood out in single-cell data, and computer docking showed it binds rutin most stably. The authors propose the score as a tool for judging patient outlook.
Catalog record
| CREATOR | Weifeng Yao, Hui Li, Yongle Zhang, Xufen Xia, Hai Wang, Zhen Zhang, Danfang Shi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |