A SARS-CoV-2 spike-derived adjuvant peptide boosts IL-17/IFN-γ immunity and improves anti-PD-L1 therapy against melanoma
Chia-Hung Chen, Tzu-Han Weng, Ta-Wei Kuo, Kai-Yao Huang, Yu-Chi Chen, Hsiao-Hsuan Huang, Hui-Ju Kao, Chen-Lin Yu, Chen-Chen Huang, Shun-Long Weng, Kuang-Wen Liao · 2025
Read A SARS-CoV-2 spike-derived adjuvant peptide boosts IL-17/IFN-γ immunity and improves anti-PD-L1 therapy against melanoma by Chia-Hung Chen, Tzu-Han Weng, Ta-Wei Kuo, Kai-Yao Huang, Yu-Chi Chen, Hsiao-Hsuan Huang, Hui-Ju Kao, Chen-Lin Yu, Chen-Chen Huang, Shun-Long Weng, Kuang-Wen Liao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12743402.txt.
Description
Vaccines against a tumor's own brake protein could teach the body to attack melanoma, but such vaccines alone stir only a weak response. Chia-Hung Chen and co-authors borrow a potent fragment from the coronavirus spike in this 2025 study to wake the vaccine up.
In mice, the combined peptide drew in killer and helper immune cells, slowed tumor growth, and cut liver spread. It also nudged macrophages toward their attacking form and made standard antibody therapy work better. Lab analyses pointed to familiar alarm pathways behind the boost. The authors propose the borrowed fragment as a general booster for cancer peptide vaccines.
Catalog record
| CREATOR | Chia-Hung Chen, Tzu-Han Weng, Ta-Wei Kuo, Kai-Yao Huang, Yu-Chi Chen, Hsiao-Hsuan Huang, Hui-Ju Kao, Chen-Lin Yu, Chen-Chen Huang, Shun-Long Weng, Kuang-Wen Liao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |