Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway
Daxin Chen, Peizhi Jia, Meiling Wang, Baojie Du, Haitao Du, Xi Huang, Jianwei Zeng, Qiaoyan Cai, Ling Zhang, Ying Zhu, Shan Lin, Dawei Lian, Jun Peng · 2025
Read Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway by Daxin Chen, Peizhi Jia, Meiling Wang, Baojie Du, Haitao Du, Xi Huang, Jianwei Zeng, Qiaoyan Cai, Ling Zhang, Ying Zhu, Shan Lin, Dawei Lian, Jun Peng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12743113.txt.
Description
Daxin Chen and co-authors study liensinine, a compound that can ease vascular remodeling in hypertension. Their 2025 paper deals with aortic stiffening, a main risk factor for cardiovascular events in hypertension.
Past work showed liensinine helps, but its mechanism was unclear. In hypertensive mice, it lowered blood pressure and pulse wave velocity and reduced aortic wall thickness. Protein tests showed it raised expression of GPX4, a guard against ferroptosis. The team traces its benefit to a ferroptosis-related TLR4 inflammatory pathway. Blocking that path of inflammation and cell death may be a way to protect blood vessels early in hypertension.
Catalog record
| CREATOR | Daxin Chen, Peizhi Jia, Meiling Wang, Baojie Du, Haitao Du, Xi Huang, Jianwei Zeng, Qiaoyan Cai, Ling Zhang, Ying Zhu, Shan Lin, Dawei Lian, Jun Peng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |