The role of ciliary function in airway epithelial defense against Pseudomonas aeruginosa
Nina Boeck, Philipp Grubwieser, Rudolf Glueckert, Erika Kvalem Soto, Thomas Sonnweber, Alexander Hoffmann, Richard Hilbe, Stefanie Dichtl, Wilfried Posch, Manfred Nairz, Igor Theurl, Zlatko Trajanoski, Guenter Weiss · 2025
Read The role of ciliary function in airway epithelial defense against Pseudomonas aeruginosa by Nina Boeck, Philipp Grubwieser, Rudolf Glueckert, Erika Kvalem Soto, Thomas Sonnweber, Alexander Hoffmann, Richard Hilbe, Stefanie Dichtl, Wilfried Posch, Manfred Nairz, Igor Theurl, Zlatko Trajanoski, Guenter Weiss (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12743103.txt.
Description
Nina Boeck and co-authors study airway cilia defense against a lung pathogen in this 2025 paper. Pseudomonas aeruginosa infects airways and weakens the tiny hairs that sweep germs out. Knowing how it does that damage points to ways to restore the sweep.
The team grew human airway organoids with beating cilia and exposed them to the bacterium. Genes for building and running cilia were turned down after contact. Microscopy showed bent structures and torn membranes, and beating slowed. A bacterial toxin called pyocyanin was one cause of the harm. A drug called roflumilast kept cilia beating near normal speed. Treated organoids also resisted bacterial invasion better.
Catalog record
| CREATOR | Nina Boeck, Philipp Grubwieser, Rudolf Glueckert, Erika Kvalem Soto, Thomas Sonnweber, Alexander Hoffmann, Richard Hilbe, Stefanie Dichtl, Wilfried Posch, Manfred Nairz, Igor Theurl, Zlatko Trajanoski, Guenter Weiss |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |