Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism
Yifei Shen, Bingyi Yao, Yuanqing Guo, Yujia Yang, Chenmeizi Liang, Junze Huang, Yuanjin Zhang, Xin Wang · 2025
Read Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism by Yifei Shen, Bingyi Yao, Yuanqing Guo, Yujia Yang, Chenmeizi Liang, Junze Huang, Yuanjin Zhang, Xin Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12741097.txt.
Description
Yifei Shen and co-authors developed a lab method to measure an antidepressant and its breakdown products in two thousand twenty-five. Escitalopram is widely used for depression and is changed by the liver in two steps. Placenta tissue may also change it, which matters in pregnancy.
Their liquid chromatography and mass spectrometry method detects the drug and both metabolites at once. Validation showed high specificity, good stability, and accuracy and precision within set limits, with no major matrix effects. Applied to rat liver, human liver, and human placenta microsomes, the method showed all three could metabolize the drug, at differing rates. Placenta metabolism was studied this way for the first time.
Catalog record
| CREATOR | Yifei Shen, Bingyi Yao, Yuanqing Guo, Yujia Yang, Chenmeizi Liang, Junze Huang, Yuanjin Zhang, Xin Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |