Clinical relevance of PLK1 in epithelial ovarian cancer
Xiaochang Shen, Jiandong Wang, Shuning Chen, Haomeng Zhang, Chunxiao Zhou, Victoria L. Bae-Jump · 2025
Read Clinical relevance of PLK1 in epithelial ovarian cancer by Xiaochang Shen, Jiandong Wang, Shuning Chen, Haomeng Zhang, Chunxiao Zhou, Victoria L. Bae-Jump (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12741083.txt.
Description
Xiaochang Shen and five co-authors study a cell-division driver in ovarian cancer in a 2025 paper. Ovarian cancer of the surface kind is the most deadly women's cancer, and fresh cures are in dire need. The driver, a kinase that steers cell splits, is made in excess in tumor tissue next to sound tissue.
High levels of the driver track with worse outlooks in early-stage cases. Blocking it in lab models stalls cell growth, jams the split cycle, harms DNA, and kills tumor cells. Paired with other drugs it works yet harder. The paper makes the case for drugs aimed at this driver.
Catalog record
| CREATOR | Xiaochang Shen, Jiandong Wang, Shuning Chen, Haomeng Zhang, Chunxiao Zhou, Victoria L. Bae-Jump |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |