Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice
Takuro Horii, Sumiyo Morita, Shinjiro Hino, Yuko Hino, Hiroto S Fukushima, Ryosuke Kobayashi, Mika Kimura, Mitsuyoshi Nakao, Yoichi Mizukami, Azusa Inoue, Izuho Hatada · 2025
Read Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice by Takuro Horii, Sumiyo Morita, Shinjiro Hino, Yuko Hino, Hiroto S Fukushima, Ryosuke Kobayashi, Mika Kimura, Mitsuyoshi Nakao, Yoichi Mizukami, Azusa Inoue, Izuho Hatada (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12741052.txt.
Description
Takuro Horii and ten colleagues present a 2025 mouse study testing whether a father's erased epigenetic marks can reappear in his children. The team built a tool that rewrites epigenetic memory directly in sperm, wiping a chemical tag, DNA methylation, from a gene region whose loss causes a growth disorder in offspring. Pups conceived from edited sperm showed the expected syndrome-like traits.
Curiously, the missing tag partly rebuilt itself as the embryo developed, hinting that some other memory instructs the repair. Removing a histone mark, H3K9me3, laid down just after fertilization blocked the repair, naming it as the instructor. Inheritance proved partial within a generation and did not pass further, the authors report.
Catalog record
| CREATOR | Takuro Horii, Sumiyo Morita, Shinjiro Hino, Yuko Hino, Hiroto S Fukushima, Ryosuke Kobayashi, Mika Kimura, Mitsuyoshi Nakao, Yoichi Mizukami, Azusa Inoue, Izuho Hatada |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |