Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss
Lucas Pari Mitre, Giovana Zanetti Ivanov, Shahin Shams, Fabio Yamaguchi, André Petraconi, Ricardo Jorge Espanhol Andrade, Eduardo Silva, Leonardo Martin, Roberta Sessa Stilhano · 2025
Read Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss by Lucas Pari Mitre, Giovana Zanetti Ivanov, Shahin Shams, Fabio Yamaguchi, André Petraconi, Ricardo Jorge Espanhol Andrade, Eduardo Silva, Leonardo Martin, Roberta Sessa Stilhano (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12740859.txt.
Description
Lucas Pari Mitre and colleagues packaged stem cells for muscle repair in two thousand twenty-five. Large muscle losses exceed the body's repair capacity. Muscle stem cells offer a promising therapy. Transplanted cells usually die or wash away quickly. Seaweed-based gel capsules can protect them. Cell balls inside gel formed the implant.
Growing cell balls with vessel cells boosted survival. A growth factor pretreatment refined the recipe further. Implants went into mice with major muscle loss. A month later, regeneration was assessed. The supportive gel improved growth factor release. Protected cells clearly outperformed unprotected expectations. Tissue engineers gain a workable delivery platform.
Catalog record
| CREATOR | Lucas Pari Mitre, Giovana Zanetti Ivanov, Shahin Shams, Fabio Yamaguchi, André Petraconi, Ricardo Jorge Espanhol Andrade, Eduardo Silva, Leonardo Martin, Roberta Sessa Stilhano |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |