Multiple Myeloma and Secondary Immunodeficiency: A Retrospective Database Analysis Assessing Burden of Infection and Treatment Patterns
Csaba Siffel, Matthew S Davids, Colin Anderson-Smits, Marta Kamieniak, Kaili Ren, Shirin Ardeshir-Rouhani-Fard, Drishti Shah, Joshua Richter, Kalyani Sen · 2025
Read Multiple Myeloma and Secondary Immunodeficiency: A Retrospective Database Analysis Assessing Burden of Infection and Treatment Patterns by Csaba Siffel, Matthew S Davids, Colin Anderson-Smits, Marta Kamieniak, Kaili Ren, Shirin Ardeshir-Rouhani-Fard, Drishti Shah, Joshua Richter, Kalyani Sen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12740457.txt.
Description
Csaba Siffel and co-authors measured the infection burden tied to weakened immunity in blood cancer patients in a 2025 database study. People with multiple myeloma often develop secondary immunodeficiency from the disease and its treatment. Using a United States health records database from 2015 to 2020, the team split patients by whether they had the immune defect. The defect group was split again by whether they received antibody replacement therapy.
At twelve months, 59 percent of the immune-defect group had infections, against 31 percent without it, and severe infections and infection hospital stays were about triple. Bacterial infections led the list. Survival ran shorter in the defect group. Patients on replacement therapy carried the heaviest burden, suggesting they were the frailest subgroup.
Catalog record
| CREATOR | Csaba Siffel, Matthew S Davids, Colin Anderson-Smits, Marta Kamieniak, Kaili Ren, Shirin Ardeshir-Rouhani-Fard, Drishti Shah, Joshua Richter, Kalyani Sen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |