Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling
Binghai Chen, Sun Gong, Jialong Zhang, Yang Zhang, Haomin Wang · 2025
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Description
Binghai Chen, Sun Gong, Jialong Zhang, Yang Zhang, and Haomin Wang test melatonin against bladder inflammation in 2025. The sleep hormone is known to calm inflammation in many organs. Whether it helps glandular cystitis, a chronic bladder condition, was untested.
A bladder cell line was inflamed with a bacterial toxin, then treated with the hormone. Inflammatory signals in the cells rose sharply under the toxin. Rats given repeated bladder toxin doses received four weeks of hormone treatment for comparison. Protein scans and pathway readouts tracked a signaling chain tied to the effect. The study frames the hormone as a candidate therapy worth deeper testing.
Catalog record
| CREATOR | Binghai Chen, Sun Gong, Jialong Zhang, Yang Zhang, Haomin Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |