MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs
Ciara F Pugh, Lukas P Feilen, Dušan Živković, Kaia F Præstegaard, Charalampos Sideris, Neil J Borthwick, Casper de Lichtenberg, Jani R Bolla, Anton A A Autzen, Henriette E Autzen · 2025
Read MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs by Ciara F Pugh, Lukas P Feilen, Dušan Živković, Kaia F Præstegaard, Charalampos Sideris, Neil J Borthwick, Casper de Lichtenberg, Jani R Bolla, Anton A A Autzen, Henriette E Autzen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12738716.txt.
Description
Pugh and colleagues published in twenty twenty-five a new helper polymer for studying proteins that sit in cell membranes. Such proteins are hard to study because removing them often damages them. Certain polymers can lift proteins straight out of the membrane in tiny native discs. The team made a polymer from two simple building blocks and named it MAASTY. Its parts mix in a scattered, statistical pattern along the chain.
MAASTY pulled a human membrane protein into discs that kept natural fats, including cholesterol. Sharp microscope imaging then revealed the protein structure in fine detail. The polymer also dissolved many fat types and many proteins from mammal cells. The authors offer it as a flexible platform. It could ease structural and functional work on membrane proteins.
Catalog record
| CREATOR | Ciara F Pugh, Lukas P Feilen, Dušan Živković, Kaia F Præstegaard, Charalampos Sideris, Neil J Borthwick, Casper de Lichtenberg, Jani R Bolla, Anton A A Autzen, Henriette E Autzen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |