Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes
Krzysztof Marianski, Joel B. Talcott, John Stein, Anthony P. Monaco, Simon E. Fisher, Dorothy V.M. Bishop, Dianne F. Newbury, Silvia Paracchini · 2025
Read Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes by Krzysztof Marianski, Joel B. Talcott, John Stein, Anthony P. Monaco, Simon E. Fisher, Dorothy V.M. Bishop, Dianne F. Newbury, Silvia Paracchini (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12738642.txt.
Description
Krzysztof Marianski and seven co-authors search for rare gene changes behind dyslexia in this twenty twenty-five study. Reading trouble affects up to one child in ten and runs in families. Common gene changes have been found before, but the role of rare ones is only now coming into view.
The team read the protein-coding genes of dozens of children with dyslexia, then checked the finds in more cases and controls. Five genes held up in the follow-up, among them one that seals cell layers and two that move calcium signals in nerve cells. The results point to new paths for how the reading brain is built.
Catalog record
| CREATOR | Krzysztof Marianski, Joel B. Talcott, John Stein, Anthony P. Monaco, Simon E. Fisher, Dorothy V.M. Bishop, Dianne F. Newbury, Silvia Paracchini |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |