Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B
Silvia Detro-Dassen, Katharina Schwandt, Philip Helmich, Stefan Düsterhöft, Walter Becker · 2025
Read Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B by Silvia Detro-Dassen, Katharina Schwandt, Philip Helmich, Stefan Düsterhöft, Walter Becker (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12738607.txt.
Description
Silvia Detro-Dassen and co-authors pin down in 2025 how a protein switch turns itself on. Switch proteins of the DYRK family must add a phosphate to one of their own tyrosine sites to work, and they do so while still folded in an off state. Two sister proteins differ sharply here: one self-activates easily, the other barely at all.
By swapping parts between the sisters and mutating single sites, the team found a shared insert segment and two neighboring prolines that decide the outcome. Giving the weak sister the strong one's insert fixed its defect. A disease-linked mutation broke the step as well, which ties the mechanism to human illness.
Catalog record
| CREATOR | Silvia Detro-Dassen, Katharina Schwandt, Philip Helmich, Stefan Düsterhöft, Walter Becker |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |