Penicillium chrysogenum originated chloro-diydropyridyl-oxopropanimidic acid derivative as a potent EPSP synthase-targeted bioherbicide against invasive weed species
Saeed Ullah Khattak, Sajjad Ahmad, Ayesha Saleem, Basmah F. Alharbi · 2025
Read Penicillium chrysogenum originated chloro-diydropyridyl-oxopropanimidic acid derivative as a potent EPSP synthase-targeted bioherbicide against invasive weed species by Saeed Ullah Khattak, Sajjad Ahmad, Ayesha Saleem, Basmah F. Alharbi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12738574.txt.
Description
Saeed Ullah Khattak and three co-authors isolate a fungus-made compound that kills weeds by blocking a plant enzyme, in this 2025 paper. The fungus, Penicillium chrysogenum living inside plant tissue, yields a chlorinated molecule whose structure the team pinned down with chromatography, mass spectrometry, and detailed NMR.
Computer docking placed the compound snugly in EPSP synthase, the enzyme that glyphosate-class herbicides target, with a strong binding score; dynamics simulations confirmed the grip held. In dishes, the compound completely stopped seed germination of sowthistle at moderate doses and strongly suppressed the invasive weed Parthenium. Under identical conditions it outperformed the synthetic herbicide 2,4-D, whose efficacy had faded. The authors present the molecule as a bioherbicide scaffold, a natural and potentially safer starting point for weed management, pending field and safety testing.
Catalog record
| CREATOR | Saeed Ullah Khattak, Sajjad Ahmad, Ayesha Saleem, Basmah F. Alharbi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |