Creatine-weighted imaging in patients with Parkinson’s disease
Kexin Wang, Nirbhay Narayan Yadav, Zijiang Yang, Ted M. Dawson, Peter van Zijl, Kelly A. Mills, Jiadi Xu, Jannik Prasuhn · 2025
Read Creatine-weighted imaging in patients with Parkinson’s disease by Kexin Wang, Nirbhay Narayan Yadav, Zijiang Yang, Ted M. Dawson, Peter van Zijl, Kelly A. Mills, Jiadi Xu, Jannik Prasuhn (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12738562.txt.
Description
Kexin Wang and seven co-authors test a new brain scan that maps creatine, a chemical tied to cell energy, in people with Parkinson's disease. Energy failure in brain cells is part of the disease, and creatine supplements have been tried as treatment with mixed results. Part of the problem is that doctors could not measure creatine across the living brain. The team's scan uses a trick with magnetic signals to do just that.
They scanned twenty-five patients and twenty-four matched healthy volunteers. One deep brain area, the caudate nucleus, showed lower creatine-linked signal in patients. Lower signals also tracked worse movement scores, the standard rating of Parkinson's severity. The authors say the scan could serve as a safe marker of brain energy health. That would help explain the disease, tune treatments, and design better trials of creatine-based therapy.
Catalog record
| CREATOR | Kexin Wang, Nirbhay Narayan Yadav, Zijiang Yang, Ted M. Dawson, Peter van Zijl, Kelly A. Mills, Jiadi Xu, Jannik Prasuhn |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |