m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy
Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang · 2025
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Description
Hui Xue and co-authors trace a gene control chain behind ulcerative colitis in a 2025 paper. A metabolic enzyme sits at the chain center in colon lining cells. Lowering the enzyme eased induced colitis in mice and calmed dish grown colon cells. Self cleaning of worn cell parts rose as swelling fell.
An RNA tagging enzyme raises the enzyme by marking its message. A partner protein tags the enzyme for stability, and both tags link in one axis. Blocking the axis lifted self cleaning and cut injury. A plant compound worked the same axis to ease colon damage. The chain offers fresh drug targets for bowel disease.
Catalog record
| CREATOR | Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |