Vaccine Platform-Dependent Differential Impact on Microbiome Diversity: Potential Advantages of Protein Subunit Vaccines
Hye Seong, Jin Gu Yoon, Eliel Nham, Yu Jung Choi, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Sooyeon Lim, Joon Young Song · 2025
Read Vaccine Platform-Dependent Differential Impact on Microbiome Diversity: Potential Advantages of Protein Subunit Vaccines by Hye Seong, Jin Gu Yoon, Eliel Nham, Yu Jung Choi, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Sooyeon Lim, Joon Young Song (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12737728.txt.
Description
Hye Seong and co-authors compare how three COVID vaccine types treat the gut microbiome after a booster. The gut's microbes shape immune response, so a vaccine that disturbs them matters. Thirty-five adults got the protein subunit booster. Their stool microbes were read before and three weeks after.
Diversity rose after the protein vaccine, a favorable shift. Helpful species gained ground while a less welcome one shrank. The viral vector vaccine had cut diversity in the team's earlier cohort, and it stayed down. The mRNA vaccine nudged diversity up briefly, then richness slid over time. The authors float the protein platform as the gentlest on the gut, at least in the short run.
Catalog record
| CREATOR | Hye Seong, Jin Gu Yoon, Eliel Nham, Yu Jung Choi, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Sooyeon Lim, Joon Young Song |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |