The Role of Posttranslational Modifications During Ebola Virus Infection
Joaquin Moreno-Contreras, Yoatzin Peñaflor-Tellez, Ricardo Rajsbaum, Eric O Freed, Abdul A Waheed · 2025
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Description
Joaquin Moreno-Contreras and co-authors present a 2025 review of how small chemical tags on proteins shape Ebola virus infection. These tags, called posttranslational modifications, are added after a protein is built. Common tags add phosphate, ubiquitin, acetyl, methyl, or sugar groups to proteins of the virus and the host cell.
The tags steer how stable a protein is, how active it is, and what it binds. They touch the immune response, cell fuel use, and cell death. Some tags help the virus copy itself, while others block key viral steps such as reading or copying its genome. By mapping these roles, the review points to new drug ideas that target the tags.
Catalog record
| CREATOR | Joaquin Moreno-Contreras, Yoatzin Peñaflor-Tellez, Ricardo Rajsbaum, Eric O Freed, Abdul A Waheed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |