Cardiac Tissue Damage in a Female Animal Post-COVID Model: Relevance of Chemokine-Mediated Inflammation
Silvia Flaj-Prados, Esperanza Herradón Pliego, Carlos Goicoechea Garcia, Eva M. Sánchez-Robles, Lars Arendt-Nielsen, César Fernández-de-las-Peñas, Visitación López-Miranda · 2025
Read Cardiac Tissue Damage in a Female Animal Post-COVID Model: Relevance of Chemokine-Mediated Inflammation by Silvia Flaj-Prados, Esperanza Herradón Pliego, Carlos Goicoechea Garcia, Eva M. Sánchez-Robles, Lars Arendt-Nielsen, César Fernández-de-las-Peñas, Visitación López-Miranda (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12737631.txt.
Description
Silvia Flaj-Prados and co-authors present a 2025 animal study of heart damage lingering a month after COVID-19 infection. Post-COVID heart problems are common and poorly explained, and women are heavily represented among the long-haul patients. A female mouse model carrying the human entry receptor offers a window.
Twelve infected mice were compared with eleven controls twenty-eight days after infection with the Omicron variant. Heart tissue was blotted for immune activation and injury markers. Two signals stood out: interleukin-6, a general inflammation messenger, and CD11d, a marker tied to chemokine-driven immune traffic. Classic upstream switches showed no significant change. The pattern suggests a smoldering, chemokine-led inflammation rather than a fresh alarm. The authors argue this route deserves attention in post-COVID heart disease.
Catalog record
| CREATOR | Silvia Flaj-Prados, Esperanza Herradón Pliego, Carlos Goicoechea Garcia, Eva M. Sánchez-Robles, Lars Arendt-Nielsen, César Fernández-de-las-Peñas, Visitación López-Miranda |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |