Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review
Michael Uwe Martin, Jürgen Frevert, Je-Young Park, Haiyan Cui, Andy Curry, Wei Qi Loh · 2025
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Description
Six authors review a quiet safety question in drugs based on botulinum toxin type A, a treatment used for both medical and cosmetic care. Newer forms of the drug now use polysorbates, man-made agents that keep the product stable. Michael Martin and co-authors ask whether these added agents can stir the immune system.
The review notes that polysorbates break down by water and by air, and the products of that decay can react with proteins and immune paths. That decay may help explain allergy-like reactions and immune responses seen in some cases. Yet firm data from real care remain sparse, and such reactions often go unnoticed. The authors call for sharper watch and clearer study of these added agents.
Catalog record
| CREATOR | Michael Uwe Martin, Jürgen Frevert, Je-Young Park, Haiyan Cui, Andy Curry, Wei Qi Loh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |