A Biomimetic Macrophage-Membrane-Fused Liposomal System Loaded with GVs-HV Recombinant Plasmid for Targeted Anti-Atherosclerosis Therapy
Yuelin Zhang, Wenting Gu, Kailing Yu, Qihong Chen, Hong Wang, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Lin Liu, Fanzhu Li, Khaled Assi, Talat Nasim, Rajendran C Gopalan, Fatma Haddad · 2025
Read A Biomimetic Macrophage-Membrane-Fused Liposomal System Loaded with GVs-HV Recombinant Plasmid for Targeted Anti-Atherosclerosis Therapy by Yuelin Zhang, Wenting Gu, Kailing Yu, Qihong Chen, Hong Wang, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Lin Liu, Fanzhu Li, Khaled Assi, Talat Nasim, Rajendran C Gopalan, Fatma Haddad (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12737165.txt.
Description
Yuelin Zhang and co-authors cloak a gene cargo in cell membrane to treat artery plaque in a 2025 study. Plaque growth can choke arteries and trigger heart attacks, and sound based popping of tiny gas sacs offers a gentle way to break plaque up.
Their vesicles fuse immune cell membrane with fat bubbles, keeping a grip protein that homes to inflamed vessel walls. Inside rides a plasmid that makes a clot dissolving drug and the gas sac parts. Sound pops the sacs at the plaque, while the drug clears debris and calms swelling. In mice, the cloaked set plus sound shrank plaque most.
Catalog record
| CREATOR | Yuelin Zhang, Wenting Gu, Kailing Yu, Qihong Chen, Hong Wang, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Lin Liu, Fanzhu Li, Khaled Assi, Talat Nasim, Rajendran C Gopalan, Fatma Haddad |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |