Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications
Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach, Anna Panchenko, Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach · 2025
Read Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications by Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach, Anna Panchenko, Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736940.txt.
Description
Rasa Giniūnaitė and co-authors ask whether DNA's stiffness helps silence genes in a 2025 paper. Most vertebrate gene switches sit in CpG islands, stretches rich in one letter pair. Painting those stretches with chemical tags is tied to genes going quiet, but the tags may also change the DNA's mechanics.
DNA must bend sharply to wrap around the protein spools that package it. The team modeled two measures of that wrapping: its energy cost and the odds of the bend happening freely. Both letter density and tag state shifted the mechanics, making some stretches easier or harder to spool. The work suggests gene control is partly a matter of bend and fit.
Catalog record
| CREATOR | Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach, Anna Panchenko, Rasa Giniūnaitė, Rahul Sharma, John H Maddocks, Skirmantas Kriaucionis, Daiva Petkevičiūtė-Gerlach |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |