PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance
Yao Liu, Hua He, Sa-Sa Zhang, Jia Zhou, Jin-Wei Zhu, Jin Xu, Hong-Jun Miao, Ji-Hui Chen, Kun Hao · 2025
Read PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance by Yao Liu, Hua He, Sa-Sa Zhang, Jia Zhou, Jin-Wei Zhu, Jin Xu, Hong-Jun Miao, Ji-Hui Chen, Kun Hao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736838.txt.
Description
Dosing a key antibiotic for sick children is tricky when their kidneys clear drugs faster than usual. Yao Liu and co-authors combine two modeling styles to guide meropenem dosing in intensive care in a 2025 study.
Data came from 101 children in two intensive care units, with 202 drug level measurements. One model learned population patterns, with body weight and kidney function shaping clearance. A second model built dosing up from body physiology. Fast kidney clearance proved common in these children. Simulations then scored many dosing plans against germ levels, seeking plans that keep drug levels above the target for the whole interval without reaching toxic levels. The dual models cross-check each other for safer dosing.
Catalog record
| CREATOR | Yao Liu, Hua He, Sa-Sa Zhang, Jia Zhou, Jin-Wei Zhu, Jin Xu, Hong-Jun Miao, Ji-Hui Chen, Kun Hao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |