Improving the Culture of Human Skin Explants for Use in Preclinical Testing of Wound Healing Treatments
Xiao Guo, Martina Hüging, Ursula Mirastschijski, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Fiorenza Rancan · 2025
Read Improving the Culture of Human Skin Explants for Use in Preclinical Testing of Wound Healing Treatments by Xiao Guo, Martina Hüging, Ursula Mirastschijski, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Fiorenza Rancan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736455.txt.
Description
Seven authors present a study in two thousand twenty-five on keeping donated human skin alive in the lab. Skin explants let researchers test wound treatments before clinical trials. But culture conditions change how cells survive and heal, and animal-based additives can distort human responses.
In dish tests with skin cell lines, human serum plus oxygen carriers helped cells migrate into scratches. The team then grew wounded skin samples in four media mixes, comparing the standard animal serum against human-based options. The aim is a cleaner, more faithful model for preclinical testing of wound therapies.
Catalog record
| CREATOR | Xiao Guo, Martina Hüging, Ursula Mirastschijski, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Fiorenza Rancan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |