Exploring Anti-Neoplastic Activity of Chitosan Nanobubbles Decorated with ICOS-Fc and Loaded with Paclitaxel in a Human and Murine Model of Melanoma
Deepika Pantham, Monica Argenziano, Foteini Christaki, Nausicaa Clemente, Chiara Colombo, Elisa Benetti, Stefania Pizzimenti, Umberto Dianzani, Ian Stoppa, Roberta Cavalli, Chiara Dianzani · 2025
Read Exploring Anti-Neoplastic Activity of Chitosan Nanobubbles Decorated with ICOS-Fc and Loaded with Paclitaxel in a Human and Murine Model of Melanoma by Deepika Pantham, Monica Argenziano, Foteini Christaki, Nausicaa Clemente, Chiara Colombo, Elisa Benetti, Stefania Pizzimenti, Umberto Dianzani, Ian Stoppa, Roberta Cavalli, Chiara Dianzani (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736336.txt.
Description
Deepika Pantham and co-authors test a targeted nanobubble drug for melanoma in this 2025 paper. Paclitaxel fights melanoma growth, spread, and blood vessel formation, but doses are harsh. A second molecule, ICOS-Fc, attacks tumor cells and their support environment. Their carrier is a chitosan nanobubble loaded with a low drug dose and coated with that molecule.
Cell tests measured survival, migration, and invasion of melanoma lines. Mouse experiments used a melanoma strain carrying a common mutation. Tumors were tracked for growth, cell division, and vessel markers after treatment. The design aims to concentrate drug action at the tumor while sparing the body. Combining a cytotoxic drug with an immune related targeting molecule is the central bet. Results span both human and mouse models.
Catalog record
| CREATOR | Deepika Pantham, Monica Argenziano, Foteini Christaki, Nausicaa Clemente, Chiara Colombo, Elisa Benetti, Stefania Pizzimenti, Umberto Dianzani, Ian Stoppa, Roberta Cavalli, Chiara Dianzani |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |