Senotherapeutics for Brain Aging Management
Timur Saliev, Prim B Singh, Junji Yamauchi · 2025
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Description
Timur Saliev and co-authors wrote a 2025 review of drugs that target worn-out cells in the aging brain. As the brain ages, some cells stop dividing but stay active and spew harmful signals. Those cells are linked to swelling, decline in thinking, and a higher risk of diseases such as Alzheimer disease.
One class of drugs kills those cells, and another calms their harmful output without killing them. In aged animals, such drugs cut brain swelling and improved memory and learning. Early human trials in Alzheimer disease are under way. The review weighs open problems, such as getting drugs into the brain and proving long-term safety.
Catalog record
| CREATOR | Timur Saliev, Prim B Singh, Junji Yamauchi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |