Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels
Anđela Tošić, Danijela Randjelović, Branka Ivković, Ana Gledović, Tijana Stanković, Jelena Đoković, Vassiliki Papadimitriou, Tanja Ilić, Snežana D Savić, Ivana Pantelić, Xiaowei Zeng · 2025
Read Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels by Anđela Tošić, Danijela Randjelović, Branka Ivković, Ana Gledović, Tijana Stanković, Jelena Đoković, Vassiliki Papadimitriou, Tanja Ilić, Snežana D Savić, Ivana Pantelić, Xiaowei Zeng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736200.txt.
Description
Anđela Tošić and ten co-authors examine what holds a nanoemulsion's structure together once it is thickened into a gel. Nanoemulsions carry drugs well, and gels are easier to use, but regulators need proof that droplets survive gelation. Ibuprofen can slip into the stabilizer layer, so its placement matters. The team made emulsions with and without the drug, then gelled them directly or indirectly with three gelling agents.
The best emulsion, at about 55 nm with low size spread, gelled cleanly by both routes with all three agents. Spectroscopy and calorimetry mapped the molecular interactions at the interface. A spin probe method located the model drug inside the surfactant and co-solvent microenvironment.
Catalog record
| CREATOR | Anđela Tošić, Danijela Randjelović, Branka Ivković, Ana Gledović, Tijana Stanković, Jelena Đoković, Vassiliki Papadimitriou, Tanja Ilić, Snežana D Savić, Ivana Pantelić, Xiaowei Zeng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |