Combination Therapy with Azithromycin and Clostridium butyricum Retains Anti-Diarrheal Efficacy but Partially Compromises Gut Microbiota Restoration Compared to Probiotics Monotherapy
Cai-Yun Wang, Meng-Yue Zhang, Hai-Ying Zhang, Yi-Meng Yang, Lu Zhang, Yi-Xuan Zhang · 2025
Read Combination Therapy with Azithromycin and Clostridium butyricum Retains Anti-Diarrheal Efficacy but Partially Compromises Gut Microbiota Restoration Compared to Probiotics Monotherapy by Cai-Yun Wang, Meng-Yue Zhang, Hai-Ying Zhang, Yi-Meng Yang, Lu Zhang, Yi-Xuan Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736042.txt.
Description
Cai-Yun Wang and others put out a mouse treatment study in 2025. They treated bacterial diarrhea with a probiotic and antibiotic. Most probiotics cannot be given with such drugs safely. One species, Clostridium butyricum, resists such drugs by nature. Diarrhea was induced with E. coli in mice. Groups got one drug, the probiotic, or both. Weight, stool, bacteria, and gut tissue were tracked. Gut germ mixes were also mapped after. Swelling signals in the gut were checked with care.
Probiotic and combined groups recovered weight fully. Diarrhea eased and germ loads returned to normal there. Antibiotic-only mice relapsed and got better in uneven ways by sex. Their colons shrank with lasting tissue damage. Joint treatment brought back germs less fully than probiotic alone. The anti-diarrhea gain held in the joint group though. Timing and pairing choices matter for gut healing.
Catalog record
| CREATOR | Cai-Yun Wang, Meng-Yue Zhang, Hai-Ying Zhang, Yi-Meng Yang, Lu Zhang, Yi-Xuan Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |