Design and Biological Evaluation of Monoterpene-Conjugated (S)-2-Ethoxy-3-(4-(4-hydroxyphenethoxy)phenyl)propanoic Acids as New Dual PPARα/γ Agonists
Sergey A Borisov, Mikhail E Blokhin, Yulia V Meshkova, Maria K Marenina, Nataliya A Zhukova, Sophia V Pavlova, Anastasiya V Lastovka, Vladislav V Fomenko, Igor P Zhurakovsky, Olga A Luzina, Mikhail V Khvostov, Dmitry A Kudlay, Nariman F Salakhutdinov, Nicola Micale · 2025
Read Design and Biological Evaluation of Monoterpene-Conjugated (S)-2-Ethoxy-3-(4-(4-hydroxyphenethoxy)phenyl)propanoic Acids as New Dual PPARα/γ Agonists by Sergey A Borisov, Mikhail E Blokhin, Yulia V Meshkova, Maria K Marenina, Nataliya A Zhukova, Sophia V Pavlova, Anastasiya V Lastovka, Vladislav V Fomenko, Igor P Zhurakovsky, Olga A Luzina, Mikhail V Khvostov, Dmitry A Kudlay, Nariman F Salakhutdinov, Nicola Micale (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736036.txt.
Description
Sergey Borisov and co-authors made and tested in 2025 new compounds that switch on two receptors at once, aiming at metabolic syndrome and type two diabetes. Most past drugs of this dual type failed trials over safety worries. Their compounds join plant-derived terpene parts to a known drug frame.
Nearly all new compounds acted on both receptors in lab tests. All were then tested in mice bred to show diabetes signs. The best compound, bearing a cumin part, cut blood sugar by raising tissue response to insulin. It also cut fat mass and blood fats, with a fairly safe profile in the tests. The authors present it as a lead for further study.
Catalog record
| CREATOR | Sergey A Borisov, Mikhail E Blokhin, Yulia V Meshkova, Maria K Marenina, Nataliya A Zhukova, Sophia V Pavlova, Anastasiya V Lastovka, Vladislav V Fomenko, Igor P Zhurakovsky, Olga A Luzina, Mikhail V Khvostov, Dmitry A Kudlay, Nariman F Salakhutdinov, Nicola Micale |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |