Stereoselective Cytotoxicity of Enantiopure 3,3-Dichloro-γ-lactams: Correlating In Vitro Activity with In Vivo Tolerability
Faïza Diaba, Elisabet Teixidó, María del Carmen Morán · 2025
Read Stereoselective Cytotoxicity of Enantiopure 3,3-Dichloro-γ-lactams: Correlating In Vitro Activity with In Vivo Tolerability by Faïza Diaba, Elisabet Teixidó, María del Carmen Morán (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12736018.txt.
Description
Faïza Diaba, Elisabet Teixidó, and María del Carmen Morán test mirror-image versions of a cancer-fighting compound family, in a 2025 paper. The compounds are gamma-lactams carrying two chlorine atoms. Mirror forms of a molecule can act very differently in the body, yet that angle is little explored for this family.
The team made the compounds with a green light-driven process and tested them on three human cancer cell lines plus two healthy control lines. One compound stood out for killing cancer cells while sparing healthy ones. Fish embryo tests matched the dish results: the same compound was the best tolerated of the pair compared. The authors credit the three-dimensional shape for the gap in both power and safety. Their lead compound is offered as a candidate for deeper preclinical study.
Catalog record
| CREATOR | Faïza Diaba, Elisabet Teixidó, María del Carmen Morán |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |