Ceftazidime-Avibactam Regimens for the Treatment of Bacteremic and Non-Bacteremic Episodes of Carbapenemase-Producing Enterobacterales Infections in Immunosuppressed Patients
Fabián Herrera, Diego Torres, María Leone, Maximiliano Gabriel Castro, Jorge López Camelo, Elena Temporiti, Natalin Grippo, Silvia Relloso, Pablo Bonvehí, Vitor Duque · 2025
Read Ceftazidime-Avibactam Regimens for the Treatment of Bacteremic and Non-Bacteremic Episodes of Carbapenemase-Producing Enterobacterales Infections in Immunosuppressed Patients by Fabián Herrera, Diego Torres, María Leone, Maximiliano Gabriel Castro, Jorge López Camelo, Elena Temporiti, Natalin Grippo, Silvia Relloso, Pablo Bonvehí, Vitor Duque (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12735816.txt.
Description
Fabián Herrera and co-authors compare two antibiotic regimens against some of the most feared hospital infections: gut bacteria that shrug off carbapenems, the antibiotics of last resort. Ceftazidime-avibactam, alone or paired with aztreonam, is the preferred answer, but evidence in immunosuppressed patients is thin. Their 2025 paper follows eighty-two infection episodes in such patients treated for at least three days.
Forty-four episodes had bacteria in the blood; thirty-eight did not. The blood cases clustered in patients with blood cancers, the others in organ transplant recipients. The main culprit in both was Klebsiella pneumoniae, most often armed with the KPC enzyme. Early response rates were high and similar, near ninety percent in both groups. Thirty-day deaths ran higher in the blood group without reaching significance. Septic shock and a cancer beyond treatment stood out as the true drivers of death.
Catalog record
| CREATOR | Fabián Herrera, Diego Torres, María Leone, Maximiliano Gabriel Castro, Jorge López Camelo, Elena Temporiti, Natalin Grippo, Silvia Relloso, Pablo Bonvehí, Vitor Duque |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |