Proteomic Insights into the Retinal Response to PRGF in a Mouse Model of Age-Related Macular Degeneration
Eduardo Anitua, Francisco Muruzabal, Sergio Recalde, María de la Fuente, Iraia Reparaz, Mikel Azkargorta, Félix Elortza, Mohammad Hamdan Alkhraisat · 2025
Read Proteomic Insights into the Retinal Response to PRGF in a Mouse Model of Age-Related Macular Degeneration by Eduardo Anitua, Francisco Muruzabal, Sergio Recalde, María de la Fuente, Iraia Reparaz, Mikel Azkargorta, Félix Elortza, Mohammad Hamdan Alkhraisat (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12735198.txt.
Description
Eduardo Anitua and co-authors use proteomics to see how plasma rich in growth factors, or PRGF, affects a damaged mouse retina. Damage was induced with sodium iodate to mimic geographic atrophy, a form of age-related macular degeneration. Groups were control, disease only, and disease plus PRGF, with tissue taken after seven days.
Mass spectrometry found 6,511 proteins in retina and retinal pigment epithelium. Disease shifted pathways tied to oxidative stress, inflammation and fibrosis. PRGF lowered those stress and inflammation pathways and turned on protective pathways, some linked to less lipid deposit build-up. The authors read PRGF as a promising option against this kind of retinal damage.
Catalog record
| CREATOR | Eduardo Anitua, Francisco Muruzabal, Sergio Recalde, María de la Fuente, Iraia Reparaz, Mikel Azkargorta, Félix Elortza, Mohammad Hamdan Alkhraisat |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |