Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations
Neshka Manchorova-Veleva, Mina Pencheva, David Baruh, Veselina Todorova, Lyubomir Vangelov, Margarita Guenova, Zhelyazko Damyanov, Donka Keskinova · 2025
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Description
Neshka Manchorova-Veleva and seven co-authors study how aging changes dentin, the hard layer under tooth enamel, in this 2025 paper. Ninety extracted human teeth were sorted into young, mature, and old groups. The team tracked three matrix proteins that guide dentin mineral building, using stained sections. Polarized light showed collagen layout, and electron microscopy showed fine structure. With age, two of the proteins rose while the third, DSPP, fell, most clearly in the dentin ringing each tubule.
Older dentin told a matching structural story. Collagen grew disordered and lost its light signature. Mineral packed inside the tubules more heavily. The authors link the protein shifts to the structural decline: as the protein balance changes, dentin loses order and mechanical strength. That helps explain why old teeth turn brittle and damage prone. For dentists treating older patients, the work names the molecular side of a familiar problem.
Catalog record
| CREATOR | Neshka Manchorova-Veleva, Mina Pencheva, David Baruh, Veselina Todorova, Lyubomir Vangelov, Margarita Guenova, Zhelyazko Damyanov, Donka Keskinova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |