Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the RYR1 Gene in a Mexican-Mestizo Population
Tania V López-Pérez, Rogelio F Jiménez-Ortega, Armando Cruz-Rangel, Diana I Aparicio-Bautista, Juan C Fernández-López, Adriana Becerra-Cervera, Juan P Reyes-Grajeda, Jorge Salmerón, Alberto Hidalgo-Bravo, Berenice Rivera-Paredez, Rafael Velázquez-Cruz, Tracy Murray-Stewart · 2025
Read Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the RYR1 Gene in a Mexican-Mestizo Population by Tania V López-Pérez, Rogelio F Jiménez-Ortega, Armando Cruz-Rangel, Diana I Aparicio-Bautista, Juan C Fernández-López, Adriana Becerra-Cervera, Juan P Reyes-Grajeda, Jorge Salmerón, Alberto Hidalgo-Bravo, Berenice Rivera-Paredez, Rafael Velázquez-Cruz, Tracy Murray-Stewart (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12734950.txt.
Description
Blood calcium levels may track with bone strength, and one gene could sit behind part of that link. Tania V López-Pérez and co-authors explored the link in a Mexican-Mestizo group in 2025. Samples came from nine hundred sixty-six health workers in a long cohort study. Bone density was measured at the hip, spine, and thigh bone neck with a standard scanner. Two variants in the RYR1 gene were typed for each person.
Higher blood calcium tracked with bone density in the data. The gene in question helps control calcium release inside cells, though its role in bone is still unclear. Past work tied its variants to low density in older women. The team checked whether the same pattern held in this group. Studies like this one refine how genes and blood measures jointly mark bone risk.
Catalog record
| CREATOR | Tania V López-Pérez, Rogelio F Jiménez-Ortega, Armando Cruz-Rangel, Diana I Aparicio-Bautista, Juan C Fernández-López, Adriana Becerra-Cervera, Juan P Reyes-Grajeda, Jorge Salmerón, Alberto Hidalgo-Bravo, Berenice Rivera-Paredez, Rafael Velázquez-Cruz, Tracy Murray-Stewart |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |