Uncovering New Antimelanoma Strategies: Experimental Insights into Semisynthetic Pentacyclic Triterpenoids
Diana Ungureanu (Similie), Larisa Bora, Sorin Dan Chiriac, Ștefana Avram, Daliana Minda, Jevgeņija Lugiņina, Vladislavs Kroškins, Māris Turks, Ioana Zinuca Magyari-Pavel, Ștefania Dinu, Cristina Adriana Dehelean, Corina Danciu · 2025
Read Uncovering New Antimelanoma Strategies: Experimental Insights into Semisynthetic Pentacyclic Triterpenoids by Diana Ungureanu (Similie), Larisa Bora, Sorin Dan Chiriac, Ștefana Avram, Daliana Minda, Jevgeņija Lugiņina, Vladislavs Kroškins, Māris Turks, Ioana Zinuca Magyari-Pavel, Ștefania Dinu, Cristina Adriana Dehelean, Corina Danciu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12734932.txt.
Description
Diana Ungureanu and co-authors tested plant-derived compounds against melanoma in two thousand twenty-five. Melanoma is the most dangerous form of skin cancer. Three natural acids from plants show anticancer promise. Their weak uptake in the body limits clinical use. The team built tweaked versions to improve those traits. Twelve new derivatives were made for testing.
The new compounds carry a phosphorus-bearing side chain. Lab tests measured their effects on melanoma cells. The parents of the series come from birch and other plants. Changes targeted how the body absorbs and handles the acids. Early results map which tweaks help or hurt activity. Such maps guide the next round of synthesis. The work sits at the chemistry and cell biology border.
Catalog record
| CREATOR | Diana Ungureanu (Similie), Larisa Bora, Sorin Dan Chiriac, Ștefana Avram, Daliana Minda, Jevgeņija Lugiņina, Vladislavs Kroškins, Māris Turks, Ioana Zinuca Magyari-Pavel, Ștefania Dinu, Cristina Adriana Dehelean, Corina Danciu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |