Chlorogenic Acid from Peucedanum japonicum Attenuates TNF-α-Induced Oxidative Stress and Inflammatory Damage in Human Dermal Fibroblasts
Neil Patrick Uy, Minseo Kang, Jang Hoon Kim, Young Ho Hoon, Sanghyun Lee, Sullim Lee · 2025
Read Chlorogenic Acid from Peucedanum japonicum Attenuates TNF-α-Induced Oxidative Stress and Inflammatory Damage in Human Dermal Fibroblasts by Neil Patrick Uy, Minseo Kang, Jang Hoon Kim, Young Ho Hoon, Sanghyun Lee, Sullim Lee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12734488.txt.
Description
Six authors test whether a coastal plant can protect skin cells from inflammation-driven aging. Peucedanum japonicum is eaten in East Asia and holds compounds that fight oxidation, but its effect on skin aging was unclear. Aging raises levels of MMP-1, an enzyme that breaks down collagen and weakens skin structure. The team profiled six major active compounds in the plant's leaves and roots, then treated human skin fibroblasts inflamed with a signaling protein and measured the damage markers.
Both leaf and root extracts calmed oxidation and inflammation, with leaves generally stronger. Chlorogenic acid stood out as the most active of the six compounds. It lowered harmful oxygen species inside the cells, cut MMP-1 release, and raised production of a key collagen gene. The authors suggest the plant could serve skincare aimed at inflammation-linked aging.
Catalog record
| CREATOR | Neil Patrick Uy, Minseo Kang, Jang Hoon Kim, Young Ho Hoon, Sanghyun Lee, Sullim Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |