Effectiveness of Natural Photosensitizers in Antimicrobial Photodynamic Therapy Within Dentistry: A Systematic Review of RCTs
Jakub Fiegler-Rudol, Dariusz Skaba, Damian Truchel, Maciej Misiołek, Rafał Wiench, Agostino Guida · 2025
Read Effectiveness of Natural Photosensitizers in Antimicrobial Photodynamic Therapy Within Dentistry: A Systematic Review of RCTs by Jakub Fiegler-Rudol, Dariusz Skaba, Damian Truchel, Maciej Misiołek, Rafał Wiench, Agostino Guida (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12734382.txt.
Description
Jakub Fiegler-Rudol and co-authors review trials of light-activated therapy using natural sensitizers against mouth biofilms, in a 2025 systematic review. In photodynamic therapy, a light-hungry compound kills microbes when lit. Natural versions, from turmeric's curcumin to chlorophyll relatives, promise gentler safety than synthetic dyes.
Of 249 records, eleven randomized trials qualified, spanning gum disease, implant inflammation, denture sore mouth, and cavity biofilms. Most showed short-term microbe cuts and modest clinical gains, on par with chlorhexidine rinses or standard care, with minimal side effects. But sensitizers, light settings, and outcomes varied too widely for pooled math, and follow-up was short. The authors back the approach as an add-on, not a replacement, and call for standardized long trials.
Catalog record
| CREATOR | Jakub Fiegler-Rudol, Dariusz Skaba, Damian Truchel, Maciej Misiołek, Rafał Wiench, Agostino Guida |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |