B-Cell Receptor-Associated Protein 31 Deficiency Aggravates Ethanol-Induced Liver Steatosis and Liver Injury via Attenuating Fatty Acid Oxidation and Glycogen Synthesis
Shubin Yu, Yaodong Xia, Chunyan Zhang, Xiangyue Han, Xiaoyue Feng, Liya Li, Hang Ma, Jialin Xu, Marco E M Peluso · 2025
Read B-Cell Receptor-Associated Protein 31 Deficiency Aggravates Ethanol-Induced Liver Steatosis and Liver Injury via Attenuating Fatty Acid Oxidation and Glycogen Synthesis by Shubin Yu, Yaodong Xia, Chunyan Zhang, Xiangyue Han, Xiaoyue Feng, Liya Li, Hang Ma, Jialin Xu, Marco E M Peluso (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12734246.txt.
Description
Shubin Yu and co-authors study a helper protein's role in alcohol-driven liver harm, in a 2025 paper. The protein, called BAP31, aids protein transport inside cells and touches fat handling. The team bred mice that lack it only in liver cells and fed them alcohol. Cell tests in a human liver line backed up the mouse work.
Mice without the protein showed worse liver injury after alcohol, with higher harm markers in blood. Fat piled up more in their livers, and genes for fat burning fell. Sugar stores in the liver also dropped, and cell stress rose. The authors conclude that the protein guards the liver by keeping fat burning and sugar storage sound.
Catalog record
| CREATOR | Shubin Yu, Yaodong Xia, Chunyan Zhang, Xiangyue Han, Xiaoyue Feng, Liya Li, Hang Ma, Jialin Xu, Marco E M Peluso |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |