Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine Fibroids
Qiwei Yang, Somayeh Vafaei, Ali Falahati, Azad Khosh, Mervat M. Omran, Tao Bai, Maria Victoria Bariani, Mohamed Ali, Thomas G. Boyer, Ayman Al-Hendy · 2025
Read Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine Fibroids by Qiwei Yang, Somayeh Vafaei, Ali Falahati, Azad Khosh, Mervat M. Omran, Tao Bai, Maria Victoria Bariani, Mohamed Ali, Thomas G. Boyer, Ayman Al-Hendy (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12733843.txt.
Description
Qiwei Yang and co-authors studied a family of proteins that read gene marks, in work on uterine fibroids published in 2025. Fibroids are the most common non-cancer growths in women of child-bearing age. The proteins in focus help switch genes on, but their role in fibroids was largely unknown.
Levels of two of these proteins differed in fibroid tissue when set against matched normal tissue from the same women. Drugs that block the proteins slowed fibroid cells more than normal cells and halted their growth cycle. Blocking also changed many gene pathways and lowered genes that build the stiff matrix around fibroid cells. The authors see the proteins as a possible new drug target.
Catalog record
| CREATOR | Qiwei Yang, Somayeh Vafaei, Ali Falahati, Azad Khosh, Mervat M. Omran, Tao Bai, Maria Victoria Bariani, Mohamed Ali, Thomas G. Boyer, Ayman Al-Hendy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |