In Pursuit of a Better Biocide Composition: Synergistic and Additive Effects of QAC-Based Formulations Against Planktonic and Biofilm Cultures
Nikita A. Frolov, Mary A. Seferyan, Elena V. Detusheva, Elizabeth Son, Ilya G. Kolmakov, Anatoly N. Vereshchagin · 2025
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Description
Nikita Frolov and co-authors report a microbiology study, published in 2025, blending disinfectant ingredients to kill stubborn microbes at lower doses. Quaternary ammonium compounds are workhorse biocides used on skin and surfaces, and better mixes could slow the spread of resistance. The team tested twelve blends of single and double forms of these compounds, some with alcohols, against seventeen bacterial and fungal strains.
The panel included highly resistant clinical strains from the notorious ESKAPEE group of pathogens. Alcohol based blends of the lead compound cut the doses needed to kill free floating and biofilm microbes many times over. Checkerboard tests confirmed true synergy for some pairs against Staphylococcus aureus, a common Gram positive threat.
Catalog record
| CREATOR | Nikita A. Frolov, Mary A. Seferyan, Elena V. Detusheva, Elizabeth Son, Ilya G. Kolmakov, Anatoly N. Vereshchagin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |