Structural Reversibility of Optic-Disc Cupping in Glaucoma: Pathophysiology, Imaging Assessment, and Clinical Implications
Gloria Roberti, Carmela Carnevale, Manuele Michelessi, Lucia Tanga, Sara Giammaria, Francesco Oddone, Etsuo Chihara, Yoshihiro Takamura · 2025
Read Structural Reversibility of Optic-Disc Cupping in Glaucoma: Pathophysiology, Imaging Assessment, and Clinical Implications by Gloria Roberti, Carmela Carnevale, Manuele Michelessi, Lucia Tanga, Sara Giammaria, Francesco Oddone, Etsuo Chihara, Yoshihiro Takamura (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12733532.txt.
Description
Gloria Roberti and co-authors review whether the cupping of the optic disc in glaucoma can partly reverse when eye pressure is lowered, in work published in 2025. Cupping is the hollowed shape the disc takes as glaucoma damages it. Reversal has been seen in children and adults after successful pressure control.
Lab models show a strong link between pressure drops and disc shape recovery. Children show the greatest reversal because their eye tissues stretch more. Adults show smaller but measurable changes after sustained pressure lowering. Modern imaging, including laser scanning and cross-section scans, confirms the shape changes track the pressure drop. The authors stress the reversal reflects tissue remodelling, not regrowth of nerve cells. It remains a useful sign that pressure control is working.
Catalog record
| CREATOR | Gloria Roberti, Carmela Carnevale, Manuele Michelessi, Lucia Tanga, Sara Giammaria, Francesco Oddone, Etsuo Chihara, Yoshihiro Takamura |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |