Transcriptional Activity of Genes Related to the Biotransformation Process in the Development of Colorectal Cancer
Grażyna Janikowska, Tomasz Janikowski, Aleksandra Kuźbińska, Mieszko Opiłka, Urszula Mazurek, Zbigniew Lorenc · 2025
Read Transcriptional Activity of Genes Related to the Biotransformation Process in the Development of Colorectal Cancer by Grażyna Janikowska, Tomasz Janikowski, Aleksandra Kuźbińska, Mieszko Opiłka, Urszula Mazurek, Zbigniew Lorenc (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12733395.txt.
Description
Grażyna Janikowska and five co-authors examine how genes that detoxify foreign and internal chemicals change their activity in colorectal cancer, in a two thousand twenty-five molecular cancer paper. The cancer is the third commonest cause of cancer death in richer countries.
Setting tumor and healthy colon transcriptomes side by side across more than twelve hundred messenger RNAs, the team found forty-six greatly altered genes spanning all three biotransformation phases. Two genes, SLC5A6 and SLC29A2, emerged as newly marked candidates, alongside one newly downregulated gene. Four genes showed diagnostic promise. Correlation patterns between detox genes differed between healthy and cancerous tissue, hinting disturbed biotransformation may help cause the disease and could inform prevention.
Catalog record
| CREATOR | Grażyna Janikowska, Tomasz Janikowski, Aleksandra Kuźbińska, Mieszko Opiłka, Urszula Mazurek, Zbigniew Lorenc |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |