Synthetic Pentatricopeptide Repeat Proteins: Building a Toolkit for Precise RNA Control
Jose M Lombana, Maureen R Hanson, Stephane Bentolila, Timofey S Rozhdestvensky · 2025
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Description
Jose Lombana, Maureen Hanson, and Stephane Bentolila present a 2025 review of synthetic PPR proteins, a toolkit for precise RNA control. In plants, natural PPR proteins bind RNA by a readable code, one block per letter. Learning that code lets engineers build proteins that bind chosen RNA on demand.
Fused to editing enzymes, the built proteins convert single RNA letters in bacteria, plants, and even human cells. They can also steady RNA or tune its reading. Small versions from early plant lineages need no helper factors, widening their use. The authors see uses from basic research to RNA disease therapy. Sharper targeting and stronger editing are the next steps.
Catalog record
| CREATOR | Jose M Lombana, Maureen R Hanson, Stephane Bentolila, Timofey S Rozhdestvensky |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |