Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment
Anastasia Mutovina, Anna Sapronova, Kseniya Ayriyants, Yulia Ryabushkina, Julia Khantakova, Polina Mezhevalova, Polina Ritter, Natalya Bondar · 2025
Read Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment by Anastasia Mutovina, Anna Sapronova, Kseniya Ayriyants, Yulia Ryabushkina, Julia Khantakova, Polina Mezhevalova, Polina Ritter, Natalya Bondar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12733220.txt.
Description
Anastasia Mutovina and seven colleagues study how a history of aggression changes the way mice handle inflammation, in a 2025 paper. Male mice with long aggressive experience, about a third of whom turned pathologically aggressive, received repeated doses of LPS, a bacterial compound that triggers inflammation. The team tracked blood counts, activity, brain immune cells, and gene expression.
The aggressive mice cleared inflammation from their blood within five days, while control mice stayed inflamed. Their brain microglia also settled back to a resting state faster, and genes tied to resolving inflammation rose. The aggression itself did not change. The authors link the pattern partly to dopamine signaling in two brain regions.
Catalog record
| CREATOR | Anastasia Mutovina, Anna Sapronova, Kseniya Ayriyants, Yulia Ryabushkina, Julia Khantakova, Polina Mezhevalova, Polina Ritter, Natalya Bondar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |