Apiin Promotes Healthy Aging in C. elegans Through Nutritional Activation of DAF-16/FOXO, Enhancing Fatty Acid Catabolism and Oxidative Stress Resistance
Yimin Qian, Xuebin Ding, Xinping Guo, Nan Bian, Ying Chen, Shaoyu Han, Wu Song, Lin Wei, Shuang Jiang · 2025
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Description
Nine researchers led by Yimin Qian test whether apiin, a plant compound found in parsley, slows aging in the small worm Caenorhabditis elegans, in a 2025 study. The team fed the compound to worms and tracked lifespan, movement, and stress responses.
At the dose they used, apiin lengthened the worms' mean lifespan by about a quarter. Treated worms built up less age pigment and moved more as they aged. They also withstood heat, light, and chemical stress better than untreated worms. Gene and chemical tests showed shifts in fat use, with stored fat falling and protective enzymes rising. The compound also switched on DAF-16, a gene regulator tied to long life in worms.
Catalog record
| CREATOR | Yimin Qian, Xuebin Ding, Xinping Guo, Nan Bian, Ying Chen, Shaoyu Han, Wu Song, Lin Wei, Shuang Jiang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |