Synthesis and Evaluation of Novel 2-((1H-1,2,4-triazol-5-yl)thio)-N-benzylidene-N-phenylacetohydrazide as Potential Antimicrobial Agents
Athul S, Bhuvaneshwari S V, Avani Anu G, Parvathi Mohanan P C, Anu R Melge, Aravind Madhavan, Bipin G Nair, Geetha Kumar, Vipin A Nair, Pradeesh Babu, Joana L C Sousa, Artur M S Silva · 2025
Read Synthesis and Evaluation of Novel 2-((1H-1,2,4-triazol-5-yl)thio)-N-benzylidene-N-phenylacetohydrazide as Potential Antimicrobial Agents by Athul S, Bhuvaneshwari S V, Avani Anu G, Parvathi Mohanan P C, Anu R Melge, Aravind Madhavan, Bipin G Nair, Geetha Kumar, Vipin A Nair, Pradeesh Babu, Joana L C Sousa, Artur M S Silva (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12732608.txt.
Description
Athul S and co-authors published a 2025 study designing a new family of candidate antimicrobial compounds. Fourteen hybrid molecules were built around a triazole ring joined to a hydrazide frame. Computer screening first picked out members with drug-like traits. All fourteen were then made in the lab, checked with spectroscopic methods, and tested against two bacteria, one Gram-negative and one Gram-positive.
Cell tests on human kidney cells gauged toxicity. One compound stood out, a fluorinated member with broad antibacterial activity. The authors present the family as a scaffold worth developing into new antimicrobials, a pressing need as resistance spreads. They also suggest the compounds might serve environmental roles in managing resistance outside the clinic.
Catalog record
| CREATOR | Athul S, Bhuvaneshwari S V, Avani Anu G, Parvathi Mohanan P C, Anu R Melge, Aravind Madhavan, Bipin G Nair, Geetha Kumar, Vipin A Nair, Pradeesh Babu, Joana L C Sousa, Artur M S Silva |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |