Underlying Mechanisms of GBA1 in Parkinson’s Disease and Dementia with Lewy Bodies: Narrative Review
Anastasia Bougea, Julien Philippe · 2025
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Description
Anastasia Bougea reviews how faults in one gene help drive Parkinson's disease and dementia with Lewy bodies, in a 2025 narrative review. Both diseases feature clumps of a misfolded protein, alpha-synuclein, in the brain. Changes in the gene, called GBA1, are a major inherited risk factor for both. The gene makes an enzyme that breaks down a fatty substance inside the cell's recycling units.
When the enzyme falls short, the fatty substance builds up, the recycling units falter, and protein clearing slows. Bougea searched four large databases from their start to November 2025, gathering about 1,650 papers. The review updates the chain from gene fault to brain damage. It aims to guide work on treatments that target the pathway.
Catalog record
| CREATOR | Anastasia Bougea, Julien Philippe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |