The Proteome of Acute Muscle Pain: Observations from Acute Hypertonic-Saline-Induced Pain in Humans
Pauline Jubin, Marie Amigo, Daniel Boulton, David A Mahns, Saad S Nagi, James S Dunn, Susanne M Krug · 2025
Read The Proteome of Acute Muscle Pain: Observations from Acute Hypertonic-Saline-Induced Pain in Humans by Pauline Jubin, Marie Amigo, Daniel Boulton, David A Mahns, Saad S Nagi, James S Dunn, Susanne M Krug (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12732361.txt.
Description
Pauline Jubin and colleagues published a pain study in 2025. They explored blood proteins during acute muscle pain. Salty fluid injected into muscle safely models pain. Healthy volunteers joined two linked study cohorts. Blood was sampled before, during, and after pain. Protein and cytokine profiles were tracked over time. A second group mapped spreading touch sensitivity carefully. Sensitivity spread across the same-side limb during pain. The other limb showed no such sensitivity gain.
Many blood proteins changed with acute pain onset. Changes pointed to metabolism and immune pathways broadly. Pain seems to trigger body-wide molecular responses quickly. Local sensitivity spread stayed on the treated side though. Systemic signals and local sensitivity may diverge mechanistically. The dataset opens new questions about pain biology.
Catalog record
| CREATOR | Pauline Jubin, Marie Amigo, Daniel Boulton, David A Mahns, Saad S Nagi, James S Dunn, Susanne M Krug |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |