Predicted Role of Mitsugumin 23 in Skeletal and Cardiac Muscle
Daiki Watanabe, Richard C. Edel, Miyuki Nishi, Hiroshi Takeshima, Samantha J. Pitt · 2025
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Description
Daiki Watanabe and colleagues present a two thousand twenty-five review of a little-known muscle protein called mitsugumin 23. The protein sits in membranes inside skeletal and heart muscle cells. It forms a leaky channel that lets calcium escape its storage compartment.
Calcium leak weakens skeletal muscle and worsens heart failure. Animals lacking this protein fare better under those leak conditions. The review weighs the protein's normal role in daily calcium handling. It also covers its part in harmful remodelling during disease. Drug researchers get a case for blocking the channel to protect muscle.
Catalog record
| CREATOR | Daiki Watanabe, Richard C. Edel, Miyuki Nishi, Hiroshi Takeshima, Samantha J. Pitt |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |